MicroRNA target prediction using thermodynamic and sequence curves
نویسندگان
چکیده
منابع مشابه
MicroRNA target prediction using thermodynamic and sequence curves
Background: MicroRNAs (miRNAs) are small regulatory RNA that mediate RNA interference by binding to various mRNA target regions. There have been several computational methods for the identification of target mRNAs for miRNAs. However, these have considered all contributory features as scalar representations, primarily, as thermodynamic or sequence-based features. Further, a majority of these me...
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Computational prediction of microRNA targets remains a challenging problem. The existing rule-based, data-driven and expression profiling approaches to target prediction are mostly approached from the gene-level. The increasing availability of RNA-seq data provides a new perspective for microRNA target prediction on the isoform-level. We hypothesize that the splicing isoform is the ultimate eff...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2015
ISSN: 1471-2164
DOI: 10.1186/s12864-015-1933-2